Award
National Cancer Institute 5R01CA259273-05
Defining epigenetic mechanisms in NPM1c mutant leukemia
Recipient
Dana-Farber Cancer Institute
Award Amount
$403,607.00
Ceiling
$403,607.00
Awarded
March 03, 2025
Identifier
5R01CA259273-05
Research project funded by the National Cancer Institute to study epigenetic mechanisms in NPM1c mutant leukemia, aiming to improve treatment strategies by understanding chromatin changes and molecular interactions.
Description
This project aims to define epigenetic mechanisms in NPM1c mutant leukemia, focusing on chromatin changes induced by mutant NPM1c and the role of Menin and MLL in this process. It involves developing a comprehensive understanding of chromatin states, identifying transcriptional activators and chromatin modifiers associated with the Menin-MLL complex, and studying the chromatin binding factor LEDGF. The goal is to improve treatment strategies for NPM1c-driven leukemia.