Award
NIH Reporter #1R21MH144466-01
Multiplexed Functional Mapping of CACNA1C Disease Variants in hiPSC-Derived Neurons
Recipient
Emory University, Atlanta, GA
Award Amount
$430,375.00
Ceiling
$430,375.00
Awarded
July 31, 2026
Identifier
1R21MH144466-01
Award to Emory University by the National Institute of Mental Health to develop a scalable assay platform for classifying CACNA1C gene variants in human neurons, enhancing understanding and treatment of neuropsychiatric disorders.
Description
Development of a next-generation neural multiplexed assay platform combining prime editing with a calcium-activity recorder to functionally classify approximately 2,000 CACNA1C variants in hiPSC-derived human neurons, aiming to advance precision diagnostics in neurodevelopmental and psychiatric disorders.