Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK136875-03
The urothelial glycosaminoglycan layer: composition and contribution to pathogen fitness during catheter-associated urinary tract infection
Recipient
State University of New York at Buffalo
Award Amount
$601,105.00
Ceiling
$601,105.00
Awarded
May 06, 2026
Identifier
5R01DK136875-03
This NIH-funded research aims to understand how the glycosaminoglycan layer in the urothelium affects bacterial infection and urosepsis in catheter-associated urinary tract infections, focusing on bacterial enzymes that degrade GAGs and their impact on infection severity.
Description
Research project to determine the contribution of glycosaminoglycans (GAGs) and microbial GAGases to infection, urosepsis, and mortality in catheter-associated urinary tract infection (CAUTI). The study will examine GAG composition, GAGase expression and specificity, and their role in CAUTI progression and severity.