Award
National Institute of General Medical Sciences 5R35GM153492-03
Phospho- and natural-variant regulation of heterotrimeric G protein signaling
Recipient
Pennsylvania State University, The
Award Amount
$396,275.00
Ceiling
$396,275.00
Awarded
February 20, 2026
Identifier
5R35GM153492-03
Research project funded by the National Institute of General Medical Sciences to study heterotrimeric G protein signaling regulation through phosphorylation and natural variation, using Arabidopsis thaliana as a model to inform therapeutic strategies for human diseases.
Description
The project aims to elucidate G protein signaling mechanisms with implications for human disease and therapeutic development, utilizing Arabidopsis as a model system. It focuses on the regulation of heterotrimeric G protein biochemistry and signaling by subunit phosphorylation and natural variation in G protein sequence, identifying regulatory paradigms that affect the G protein cycle, heterotrimer interactions, subcellular localization, and coupling with other proteins.