Award
NIH Reporter #3R01AG075927-04S1
Whole Genome Sequencing and Admixture Analyses of Neuropathologic Traits in Diverse Cohorts in USA and Brazil
Recipient
Rush University Medical Center, Chicago, IL, United States
Award Amount
$1,226,060.00
Ceiling
$1,226,060.00
Awarded
August 11, 2026
Identifier
3R01AG075927-04S1
Award for genomic research to identify molecular drivers of Alzheimer's disease and related dementias using whole genome sequencing in diverse populations in the USA and Brazil.
Description
This project aims to identify genes and proteins that drive common Alzheimer's disease and related dementias (AD/ADRD) pathologic traits by leveraging whole genome sequencing (WGS) data from diverse cohorts in the USA and Brazil, including admixed populations. The study will generate WGS on additional participants, perform admixture mapping, determine telomere length associations, and explore rare variants and mitochondrial DNA links to AD/ADRD traits.