Award
National Institute of Allergy and Infectious Diseases 1R21AI194255-01
Nutrient acquisition and cyclic nucleotide signaling in Treponema pallidum as underpinnings of stealth pathogenicity
Recipient
University of Connecticut School of Medicine
Award Amount
$457,875.00
Ceiling
$457,875.00
Awarded
July 23, 2025
Identifier
1R21AI194255-01
NIH awarded a multiyear grant to University of Connecticut School of Medicine to study nutrient acquisition and signaling in Treponema pallidum, aiming to understand syphilis pathogenesis and persistence.
Description
This NIH grant project aims to investigate fundamental aspects of syphilis pathogenesis, focusing on nutrient acquisition and cyclic nucleotide signaling in Treponema pallidum. The research will characterize mutants to understand their contributions to growth, adherence, and infectivity, and explore regulatory pathways involving cyclic nucleotides to elucidate mechanisms of persistence and pathogenicity.