Award
National Institute of Diabetes and Digestive and Kidney Diseases 4R01DK140244-03
Control of allelic Gsα expression for regulating hormone signaling
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$1,031,144.00
Ceiling
$1,031,144.00
Awarded
July 28, 2026
Identifier
4R01DK140244-03
A research project funded by NIDDK to study the regulation of Gsα expression from the GNAS gene in hormone-responsive tissues, including the development of stem cell models to understand methylation and hormone signaling mechanisms.
Description
This project aims to elucidate mechanisms regulating Gsα production from the GNAS gene in hormone-responsive tissues, focusing on allelic Gsα expression regulation, methylation mechanisms, and tissue-specific hormone signaling pathways. The project involves developing human embryonic stem cell models and induced pluripotent stem cells to study GNAS methylation and Gsα expression regulation.