Award
NIH Reporter #1R01HL186195-01
Dedicator of Cytokinesis 2 (DOCK2) in Aortic Valve Calcification
Recipient
COLUMBIA
Award Amount
$550,765.00
Ceiling
$550,765.00
Awarded
June 01, 2026
Identifier
1R01HL186195-01
Award for research on the role of DOCK2 in aortic valve calcification and testing a small-molecule inhibitor as therapy, funded by NHLBI for $550,765.
Description
This project aims to elucidate the role of DOCK2 in aortic valve calcification and evaluate a small-molecule inhibitor as a therapeutic candidate. The project is funded by NHLBI with a total award amount of $550,765, starting June 1, 2026, and ending February 28, 2027. The project involves advanced in vivo models, genetic manipulation, and pharmacologic inhibition to understand and target AVC mechanisms.