Award
NIH Reporter #11212191
Cognate CD4+ T cell help to macrophages during tuberculosis
Recipient
State University of New York Stony Brook
Award Amount
$161,774.00
Ceiling
$161,774.00
Awarded
July 17, 2026
Identifier
11212191
Research project funded by NIAID to study the role of CD4+ T cells in helping macrophages during tuberculosis, aiming to discover new therapeutic targets.
Description
This project investigates the immune mechanisms involving CD4+ T cells and macrophages, focusing on how CD40 activation influences glycolytic gene expression in infected macrophages and how this affects Mtb survival. The research aims to identify bacterial stress response pathways and bacterial genes involved in aldehyde detoxification, which could lead to new therapeutic strategies.