NIH Reporter #11332689

Regulation of B cell Responses in SLE and Other Autoimmune Diseases

Award for research on B cell responses in autoimmune diseases using single cell sequencing to study epigenetic and transcriptomic changes pre- and post-biologic therapy.

Description

This project involves comprehensive single cell sequencing to analyze B cell responses in SLE and autoimmune diseases, focusing on epigenetic and transcriptomic profiling pre- and post-therapy with biologics such as Anifrolumab and Belimumab. The goal is to understand the resetting of epigenetic features to a healthy state and define gene pathways and transcription factor networks involved.

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