Eunice Kennedy Shriver National Institute of Child Health and Human Development 5K99HD111676-02

Integrating cell identities and morphodynamics through extracellular cues

NIH grant awarded to Caltech for research on how extracellular matrix cues regulate cell identity and morphodynamics in early mammalian embryos to understand embryogenesis and prevent pregnancy loss.

Description

This NIH grant supports research to determine how the embryonic basement membrane coordinates cell behaviors and facilitates pattern formation during early mammalian embryogenesis using advanced imaging, genetic manipulations, spatial transcriptomics, and mathematical modeling. The project aims to map cell behaviors, define the role of the basement membrane, generate in situ fate maps, build integrative models, and explore germ layer formation during gastrulation.

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