Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5F31HD113285-02
Dissecting the role of ZCWPW1 in oocyte quality, fertility and ovarian physiology.
Recipient
University of Michigan at Ann Arbor, MI, United States
Award Amount
$43,588.00
Ceiling
$43,588.00
Awarded
July 18, 2025
Identifier
5F31HD113285-02
The award supports research on the role of the protein ZCWPW1 in female meiosis and ovarian function, investigating its impact on oocyte quality, fertility, and ovarian reserve, which has relevance to infertility and ovarian health.
Description
This project aims to examine the role of ZCWPW1 in female meiosis, focusing on homolog pairing, recombination, meiotic prophase progression, and oocyte elimination or survival. The study uses genetic models and molecular techniques to understand ZCWPW1's function in oocyte quality control and ovarian reserve establishment and maintenance, with implications for human infertility and ovarian physiology.