Award
National Institute of Allergy and Infectious Diseases 1R21AI191589-01A1
A versatile bimodal QF/QS gene expression system for insect and vertebrate models based on conditional protein self-splicing
Recipient
Texas A&M University Health Science Center, College Station, TX
Award Amount
$416,894.00
Ceiling
$416,894.00
Awarded
February 09, 2026
Identifier
1R21AI191589-01A1
The award funds a project to develop a versatile gene expression system using conditional protein self-splicing to improve temporal control in insect and vertebrate models, enhancing research relevant to human health.
Description
This project aims to re-engineer the Q-system by incorporating temperature-sensitive self-splicing intein modules (INTts), tested for efficacy in Drosophila melanogaster and transferred to zebrafish Danio rerio. The goal is to provide temporal control for gene and cell function analysis relevant to human health, overcoming limitations such as toxicity and lack of effective suppression.