Award
National Institute of Allergy and Infectious Diseases 1R01AI198337-01
Deep learning-enabled protein design for targeted depletion of antibiotic resistant bacterial pathogens
Recipient
University of Washington
Award Amount
$804,183.00
Ceiling
$804,183.00
Awarded
July 16, 2026
Identifier
1R01AI198337-01
A grant awarded to the University of Washington to develop deep learning-designed chimeric proteins (BacTACs) targeting antibiotic-resistant bacteria by enhancing immune-mediated bactericidal activity.
Description
This project aims to leverage deep learning for designing chimeric proteins called BacTACs to combat antibiotic-resistant bacteria by engaging host immune responses. The project involves designing high-affinity binders to bacterial surface proteins and host immune receptors to create chimeric proteins that redirect immune responses for rapid clearance of antibiotic-resistant pathogens such as Acinetobacter baumannii and Staphylococcus aureus.