Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK107603-10
Mucosal Macrophages and Tertiary Lymphoid Structures in IBD
Recipient
University of Massachusetts Medical School Worcester, MA, USA
Award Amount
$546,982.00
Ceiling
$546,982.00
Awarded
February 20, 2025
Identifier
5R01DK107603-10
This NIH grant supports research on the role of mucosal macrophages in the formation and function of tertiary lymphoid structures in IBD, aiming to understand their contribution to disease pathogenesis.
Description
The project aims to unravel the mechanisms that drive tertiary lymphoid structures (TLS) formation and function in mouse models of inflammatory bowel disease (IBD) by targeting differentiation and function of mucosa-resident (CX3CR1hi) macrophages shown to induce TLS.