Award
NIH Reporter #2R01AG070149-04
Multiorgan Photon Counting CT and Machine Learning to Elucidate Aging Mechanisms and Interventions
Recipient
Not specified
Award Amount
$612,746.00
Ceiling
$612,746.00
Awarded
June 11, 2026
Identifier
2R01AG070149-04
Award for research project using photon-counting CT and machine learning to study aging mechanisms and interventions focusing on liver health and systemic aging.
Description
This project investigates how liver health influences systemic aging across the heart, brain, and bone in genetically engineered APOE mouse models. It uses advanced photon-counting CT imaging, AI-based multiorgan aging clocks, and molecular profiling to test whether early hepatic changes drive age-related decline in other organs. The project aims to reveal modifiable liver-centered pathways of aging, identify imaging-based biomarkers, and inform interventions for age-related diseases.