Award
National Institute of General Medical Sciences 5R35GM156386-02
Understanding general principles in receptor tyrosine kinase signaling through structural and functional studies
Recipient
UT SOUTHWESTERN MEDICAL CENTER
Award Amount
$574,000.00
Ceiling
$574,000.00
Awarded
February 09, 2026
Identifier
5R35GM156386-02
Research project to explore the structural and functional principles of receptor tyrosine kinases (RTKs) using cryo-EM and other techniques to understand activation, signaling specificity, and clustering, aiming to inform new therapeutic development.
Description
This project involves structural and functional studies of receptor tyrosine kinases (RTKs) to understand their activation mechanisms and regulation, utilizing cryo-EM, biochemistry, biophysics, and cell biology techniques. The research aims to answer fundamental questions about RTK conformational changes, signaling specificity, and clustering, with the goal of informing therapeutic development.