Award
National Cancer Institute 5F32CA298648-02
Elucidating the role of an essential transcription factor in SWI/SNF -mutant rhabdoid tumors
Recipient
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Award Amount
$79,348.00
Ceiling
$79,348.00
Awarded
June 26, 2026
Identifier
5F32CA298648-02
This award supports research to understand the role of a key transcription factor in rhabdoid tumors caused by SMARCB1 loss, aiming to uncover mechanisms and therapeutic targets.
Description
Mutations in chromatin regulatory genes frequently cause cancer. This is true of the highly lethal childhood rhabdoid tumor, which is caused by the loss of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex. The project aims to investigate a transcription factor that is essential in RTs, interacts with a repressive chromatin-regulatory complex, and functions as a transcriptional activator. The research will explore the mechanism of this transcription factor and its role in SMARCB1 loss, using genome-wide approaches and cell line models.