Award
National Institute on Aging 5K01AG078485-05
Metabolic Vulnerability and Effects of APOE in Human Neurons with Impaired Endocytic Recycling
Recipient
Oregon Health & Science University, Portland, OR, United States
Award Amount
$124,859.00
Ceiling
$124,859.00
Awarded
April 28, 2026
Identifier
5K01AG078485-05
NIH funded research to study metabolic stress and genetic factors affecting neuronal energy metabolism and vulnerability in neurodegenerative diseases, focusing on APOE effects and endocytic recycling.
Description
This NIH grant project aims to identify genetic targets that maintain cellular energy levels in neurons, focusing on the impact of endocytic recycling disruptions and APOE genotype on metabolic vulnerability related to neurodegenerative diseases such as Alzheimer's and Parkinson's. The research explores therapeutic potential to prevent neuronal vulnerability and decline.