Award
National Institute of Allergy and Infectious Diseases 3R01AI176934-03S1
Virologic and immunologic impacts of active viral persistence in lung AMs of HIV-1-infected, cART-suppressed individuals
Recipient
STATE UNIVERSITY OF NEW YORK AT BUFFALO
Award Amount
$152,468.00
Ceiling
$152,468.00
Awarded
April 23, 2026
Identifier
3R01AI176934-03S1
This NIH grant supports research on HIV-1 persistence in lung alveolar macrophages of therapy-suppressed individuals, aiming to understand viral reservoirs and rebound mechanisms to inform targeted elimination strategies.
Description
The project focuses on the persistence of HIV-1 in tissue reservoirs of therapy-suppressed, aviremic individuals, particularly in alveolar macrophages. The study aims to characterize proviral landscapes, effects of ongoing viral transcription, and impact on viral rebound. The project involves state-of-the-art molecular, cellular, and immunological methods. The grant is part of NIH's efforts to understand HIV persistence and develop targeted elimination strategies.