Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK135958-04
Comprehensive quantification of fuel use in cold-induced thermogenesis in vivo
Recipient
University of Pennsylvania
Award Amount
$572,297.00
Ceiling
$572,297.00
Awarded
March 26, 2026
Identifier
5R01DK135958-04
Research project funded by NIDDK to study fuel use in cold-induced thermogenesis in mice, focusing on quantifying metabolic fluxes and tissue-specific fuel consumption to understand heat generation mechanisms.
Description
This project aims to quantify systemic metabolic fluxes during cold exposure in mice using isotope-labeled fuels and kinetic studies, hypothesizing that cold-induced thermogenesis (CIT) is largely fueled from fat stores but critically dependent on carbohydrate sources from the liver. The study will provide a foundational quantitative framework for understanding how animals generate heat by measuring whole-body fuel turnover and fuel use in individual tissues during CIT.