Award
NIH Reporter #1ZIAAG000946-18
Pathogenic Mechanisms of ALS and Motor Neuron Diseases
Recipient
National Institute on Aging (NIA), United States
Award Amount
$25,007.00
Ceiling
$25,007.00
Awarded
October 04, 2023
Identifier
1ZIAAG000946-18
Research project funded by the National Institute on Aging to study the pathogenic mechanisms of ALS and motor neuron diseases through a mouse model expressing the VAPB P56S mutation, aiming to uncover molecular pathways and develop targeted therapies.
Description
This project investigates the molecular mechanisms underlying amyotrophic lateral sclerosis (ALS) and related motor neuron diseases, focusing on the VAPB P56S mutation using a homozygous knock-in mouse model. The study involves behavioral, histological, cellular, and molecular analyses to understand disease pathways and identify potential therapeutic targets to preserve corticospinal motor neuron function and slow disease progression.