Award
National Institute of General Medical Sciences 5R35GM137912-07
Dynamic modulation of HCN4 and ASICs
Recipient
University of Colorado Denver, Aurora, CO
Award Amount
$404,095.00
Ceiling
$404,095.00
Awarded
May 20, 2026
Identifier
5R35GM137912-07
Research grant to study modulation of ion channels ASICs and HCN4 to develop therapies for stroke and pain by investigating lipid interactions, channel assembly, and structural features.
Description
The project aims to understand how cellular factors like lipids and protein partners alter channel function, aiding in the development of therapies targeting these channels. It focuses on ASICs and HCN channels, which modulate cellular excitability and play roles in pain sensing, heart rate, and ischemic cell death.