Award
National Heart, Lung, and Blood Institute 5R01HL174917-03
Early Developmental Risk for Adult Cardiovascular Disease: High risk Subgroups, Biomarkers, and Mechanisms
Recipient
Brown University, Providence, RI, United States
Award Amount
$1,782,161.00
Ceiling
$1,782,161.00
Awarded
May 18, 2026
Identifier
5R01HL174917-03
A longitudinal study funded by the National Heart Lung and Blood Institute to investigate early developmental risk factors in infants born small for gestational age and their link to adult cardiovascular disease, using biomarker analysis and clinical assessments.
Description
This project seeks to generate new insights regarding the early identification and prevention of adult coronary heart disease (CHD). It focuses on infants born small for gestational age (SGA) and their increased risk for CHD and cardiovascular disease (CVD) mortality later in life. The study will evaluate biomarkers from prenatal and neonatal serum samples to understand mechanisms such as placental dysfunction, fetal hypoxia, and metabolic programming.