Award
National Institute of Allergy and Infectious Diseases 1R21AI201990-01
Gain-of-function MRGPRX2 mutations in drug induced hypersensitivity reactions
Recipient
University of Pennsylvania
Award Amount
$243,750.00
Ceiling
$243,750.00
Awarded
July 03, 2026
Identifier
1R21AI201990-01
The award funds research to develop humanized mouse models with SNPs in the MRGPRX2 gene to study their impact on drug-induced hypersensitivity reactions, aiming to understand mechanisms and develop therapeutic strategies.
Description
This project involves developing mouse models with specific SNPs in the MRGPRX2 gene to study their role in drug hypersensitivity reactions. It utilizes CRISPR/Cas9 gene editing and humanized mouse models.