Award
NIH Reporter #1F31NS139645-01A1
Investigating the Molecular and Cellular Basis of RNA Exosome-linked Pontocerebellar Hypoplasia Type1b in Human 3D Brain Organoids
Recipient
University of Southern California
Award Amount
$45,241.00
Ceiling
$45,241.00
Awarded
August 04, 2025
Identifier
1F31NS139645-01A1
Award for research investigating the molecular and cellular basis of RNA exosome-linked Pontocerebellar Hypoplasia Type1b using human 3D brain organoids, focusing on gene expression and neuronal differentiation defects.
Description
This project aims to elucidate the role of the RNA exosome in neuronal cell fate determination and its implications in Pontocerebellar Hypoplasia Type 1b. The research focuses on the RNA exosome's function in processing specific target RNAs essential for progenitor proliferation and neuronal differentiation within the brain, using human induced pluripotent stem cells with disease-causing mutations.