Award
National Institute of Neurological Disorders and Stroke 5R01NS115746-05
Neuropeptides as axonal determinants for oligodendrocyte differentiation and myelination
Recipient
University of California, San Francisco
Award Amount
$361,665.00
Ceiling
$361,665.00
Awarded
November 15, 2024
Identifier
5R01NS115746-05
Research project funded by NINDS to study how neuropeptides called dynorphins regulate oligodendrocyte differentiation and myelination in the central nervous system, potentially revealing mechanisms of CNS development and therapeutic targets.
Description
This project focuses on investigating the role of neuropeptides, specifically dynorphins, in oligodendrocyte differentiation and myelination in the CNS. It aims to understand how dynorphins influence gene expression and cellular fate by binding to G-protein coupled receptors, and their role in activity-dependent myelination.