Award
National Institute on Aging 5K99AG095208-02
Cell-type-specific dysregulation and genetic control of alternative polyadenylation in neurodegeneration
Recipient
Harvard Medical School, Boston, MA, United States
Award Amount
$125,901.00
Ceiling
$125,901.00
Awarded
May 12, 2026
Identifier
5K99AG095208-02
This NIH grant supports research on alternative polyadenylation dysregulation in neurodegenerative diseases like Alzheimer's and Parkinson's, aiming to map genetic risk loci and understand disease mechanisms using advanced sequencing data.
Description
The research aims to repurpose existing single-cell and whole genome sequencing datasets to map altered 3’UTR choice in neurodegeneration, identify variants regulating 3’UTR choice, and understand downstream effects on disease. This work is relevant to the mission of the NIA and public health, as it enhances understanding of molecular layers involved in neurodegeneration and may inform therapeutic interventions.