Award
National Institute of Allergy and Infectious Diseases 1R21AI193440-01A1
Deciphering Phagosomal Membrane Repair Pathways during Mycobacterium tuberculosis Infection Using High-Throughput Single Cell and Single Phagosome Analysis
Recipient
University of Maryland, College Park
Award Amount
$234,000.00
Ceiling
$234,000.00
Awarded
May 26, 2026
Identifier
1R21AI193440-01A1
The award supports research to understand how human macrophages repair phagosomal membranes damaged by Mycobacterium tuberculosis, using microscopy, genetic screening, and bioinformatics to elucidate host cell repair mechanisms during infection.
Description
This project aims to characterize the host cell membrane repair mechanisms in response to phagosomal membrane damage induced by Mycobacterium tuberculosis (Mtb). It involves advanced microscopy, bioinformatics, and genetic screening to study phagosomal membrane repair pathways in human macrophages, focusing on host-pathogen interactions and tuberculosis.