Award
National Cancer Institute 5R01CA234266-09
Molecular modulator of RAD51 in maintaining genome stability
Recipient
Rosalind Franklin University of Medicine & Science
Award Amount
$374,585.00
Ceiling
$374,585.00
Awarded
January 20, 2026
Identifier
5R01CA234266-09
NIH grant awarded to study molecular mechanisms of RAD51 in genome stability, focusing on replication fork protection and cancer therapy resistance.
Description
This NIH grant project aims to elucidate the molecular mechanisms of replication fork protection to maintain genome stability, focusing on RAD51 recruiting mechanisms and the calcium-sensing signaling pathway. The research involves structural biology, genomic mapping, and functional assays to understand nuclease regulation at stalled replication forks, with implications for cancer therapy resistance.