NIH Reporter #5R21DC021730-02

Characterization of the cochlear aqueduct

Research project to characterize the cochlear aqueduct's properties and age-related changes in mice using advanced imaging and molecular techniques, aiming to inform therapeutic delivery strategies for cochlear disorders.

Description

This project aims to systematically characterize the properties and mechanisms underlying the influx pathway of the cochlear aqueduct (CA) and how age may alter its function in mice. It will address key gaps in understanding of the cochlear aqueduct using pre-clinical MRI and laser capture microscopy coupled with single cell sequencing technologies. The study will establish a fundamental basis for understanding the CA as a passage route to and from the cochlea and its potential for pre-clinical delivery strategies to treat cochlear disorders.

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