Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 1R21AR087144-01
Scalable imaging approach to measure muscle bioenergetics in CKD.
Recipient
Albert Einstein College of Medicine
Award Amount
$556,651.00
Ceiling
$556,651.00
Awarded
March 04, 2026
Identifier
1R21AR087144-01
Award to Albert Einstein College of Medicine to develop a novel MRI-based method to measure muscle bioenergetics in chronic kidney disease patients, aiming to assess mitochondrial function and improve clinical interventions.
Description
This project aims to develop and validate a novel MRI-based method using chemical exchange saturation transfer (CEST) MRI to quantify muscle bioenergetics, specifically phosphocreatine and creatine pools, to assess mitochondrial function in CKD patients. The research objectives include quantifying deficits in skeletal muscle mitochondrial bioenergetics in patients with severe CKD, defining the association between muscle oxidative capacity and physical function impairment, and developing a scalable, in vivo mitochondrial function measurement method for widespread testing.