Award
National Institute of Diabetes and Digestive and Kidney Diseases 2R01DK046865-32
Function of Putative Determinant in Hematopoiesis
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY, United States
Award Amount
$642,909.00
Ceiling
$642,909.00
Awarded
May 19, 2026
Identifier
2R01DK046865-32
Research project funded by NIDDK to study the role of EKLF in gene regulation during hematopoiesis and its implications for blood disorders and developmental anomalies.
Description
This project investigates the molecular and biological functions of Erythroid Krüppel-like Factor (EKLF; KLF1), a global regulator of genes essential for the erythroid program. The study builds on previous findings that EKLF integrates transcriptional and epigenetic inputs for gene activation, associates with repressor proteins, and may influence disorders of sexual development in patients with CDA type IV. The research employs molecular, biochemical, cellular, and genetic approaches, utilizing primary cells, mouse models, and human pluripotent lines to elucidate EKLF’s role in gene expression, epigenetics, and systemic effects.