Award
National Institute of Allergy and Infectious Diseases (NIAID) 5U01AI186999-02
Multiscale Modeling of Influenza Neutralizing Antibody and Fc Effector Biology
Recipient
Duke University, Durham, NC, United States
Award Amount
$1,058,506.00
Ceiling
$1,058,506.00
Awarded
December 29, 2025
Identifier
5U01AI186999-02
NIH research grant to develop multiscale computational models predicting antibody responses to improve influenza vaccine design.
Description
This project will develop computational models to understand antibody diversity, function, and coordination at the molecular, tissue, and individual scales from an extensive collection of human datasets. By providing in silico platforms for generating antibody repertoires, modeling mucosal defense, and simulating infection outcomes, these models will rapidly accelerate the development of more effective influenza vaccines.