Award
National Institute of Allergy and Infectious Diseases (NIAID) 5R01AI187725-02
Biodegradable polymeric microparticles comprised of acetalated dextran induce immune tolerance
Recipient
UNIV OF NORTH CAROLINA CHAPEL HILL
Award Amount
$516,506.00
Ceiling
$516,506.00
Awarded
December 23, 2025
Identifier
5R01AI187725-02
NIH grant awarded to UNIV OF NORTH CAROLINA CHAPEL HILL for research on biodegradable polymeric microparticles to induce immune tolerance, focusing on autoimmune diseases like multiple sclerosis.
Description
The project focuses on antigen-specific treatment of autoimmune diseases, particularly multiple sclerosis, using Ace-DEX microparticles. The project aims to synthesize biomaterial particles, characterize protein corona, optimize therapy, and elucidate mechanisms of action. The project involves in vivo and in vitro studies, including RNA-seq and knockout mice experiments.