Award
National Institute of General Medical Sciences 5R01GM114564-09
Analysis of mRNP granule clearance, vacuolar RNA decay and TDP-43 turnover
Recipient
University of Arizona, Tucson, AZ
Award Amount
$310,873.00
Ceiling
$310,873.00
Awarded
May 02, 2025
Identifier
5R01GM114564-09
The project investigates cellular clearance mechanisms of RNA and protein complexes, particularly mRNP granules and TDP-43, to understand their roles in diseases like ALS and cancer, aiming to identify new therapeutic targets.
Description
This NIH grant project aims to elucidate mechanisms of RNA and protein clearance pathways, focusing on stress granules, P-bodies, and TDP-43 degradation, with potential therapeutic implications for ALS and cancer.