Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1R21HD117691-01A1
Imaging Biomarker for Determining Antiretroviral-induced Neurodevelopmental Impairments
Recipient
University of Nebraska Medical Center
Award Amount
$422,125.00
Ceiling
$422,125.00
Awarded
July 01, 2025
Identifier
1R21HD117691-01A1
Development of a novel CEST MRI technique to detect ARV-induced neurodevelopmental impairments in rodent embryos, aiming to identify early biomarkers of neurotoxicity.
Description
This project aims to develop a non-invasive chemical exchange saturation transfer (CEST) MRI technique to identify neurodevelopmental impairments caused by antiretroviral drugs (ARVs) in rodent embryos during gestation. The goal is to uncover early biomarkers of neurotoxicity and understand the underlying mechanisms.