Award
National Institute of Allergy and Infectious Diseases 5R01AI179986-03
The novel role of MIF-CD74 inflammatory pathway in immune regulation
Recipient
Brigham and Women's Hospital
Award Amount
$420,683.00
Ceiling
$420,683.00
Awarded
December 05, 2025
Identifier
5R01AI179986-03
NIH research grant awarded to Brigham and Women's Hospital to study the MIF-CD74 inflammatory pathway's role in immune regulation and develop therapies to improve transplant tolerance.
Description
This project investigates the role of a novel inflammatory pathway involving macrophage migration inhibitory factor (MIF) and its receptor CD74 in immune regulation, particularly in the context of transplantation rejection. The study aims to understand how MIF-CD74 signaling affects regulatory T cell (Treg) stability and effector T cell (Teff) function, with the goal of developing targeted therapies to promote transplant tolerance.