Award
National Heart, Lung, and Blood Institute 5R01HL164404-04
Targeting T2 inflammation-evoked mechanical endotypes of ASM shortening in asthma
Recipient
Rutgers Biomedical and Health Sciences, Newark, NJ, United States
Award Amount
$533,871.00
Ceiling
$533,871.00
Awarded
April 22, 2026
Identifier
5R01HL164404-04
Research project focused on asthma, investigating molecular mechanisms of airway smooth muscle function and drug resistance to improve therapies for severe asthma.
Description
The project aims to understand the molecular mechanisms of excitation-contraction (E-C) coupling in human airway smooth muscle (HASM), focusing on inflammation-dependent and -independent pathways, and to identify new drug targets to treat β2-agonist insensitivity in severe asthma. The research leverages advanced micromechanical and genomics techniques in human lung slices and primary cells.