Award
National Heart, Lung, and Blood Institute 5R01HL177834-02
Dysfunctional Renin-Angiotensin System in Septic Shock
Recipient
Wake Forest University Health Sciences
Award Amount
$758,030.00
Ceiling
$758,030.00
Awarded
July 16, 2026
Identifier
5R01HL177834-02
NIH grant awarded to Wake Forest University Health Sciences to study the dysfunctional renin-angiotensin system in septic shock, aiming to improve treatment and patient outcomes through biomarker development and comparative analysis of treatment options.
Description
This NIH research grant opportunity focuses on septic shock and the renin-angiotensin system, aiming to improve understanding and treatment by investigating the renin-angiotensin-aldosterone system (RAAS). The study compares the benefits of exogenous Angiotensin II versus norepinephrine in septic shock patients, assessing protein levels of RAAS components and immune responses to develop more precise biomarkers and treatment regimens to improve patient outcomes.