Award
Virginia Commonwealth University 1R21DE035939-01
Mapping and Modulating Endothelial Dysfunction in Peri-implantitis
Recipient
Virginia Commonwealth University
Award Amount
$446,611.00
Ceiling
$446,611.00
Awarded
July 09, 2026
Identifier
1R21DE035939-01
Award for research on endothelial dysfunction in peri-implantitis using advanced molecular and AI techniques to develop therapeutic interventions.
Description
This project aims to construct a spatially resolved, multimodal atlas of peri-implantitis vasculopathy, assess CD38+ vascular endothelial cells, and evaluate pharmacologic interventions to reverse pro-inflammatory states. The work involves spatial transcriptomics, proteomics, AI tools, and functional assays, with potential relevance to other chronic diseases involving endothelial injury.